Gastrointestinal Physiology 2 E Pdf Download LINK

Gastrointestinal Physiology 2 E Pdf Download LINK

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In the present study, we administered both A1 and A2 -casein at a ratio of 4:1. Milk containing A1 -casein at a ratio of 4:1 may potentially be a more realistic representation of dairy products in the western diet. The results of this trial suggest that the consumption of milk containing A1 -casein at a ratio of 4:1 worsens the gastrointestinal symptoms of lactose intolerant subjects compared with a milk product containing only the A2 -casein type. However, because the present study did not test the effects of a 4:1 ratio of A1 -casein to A2 -casein, there is a possibility that A1 -casein at a lower ratio (e.g., a ratio of 2:1) may worsen gastrointestinal symptoms as well. The consumption of milk containing only the A2 -casein type did not worsen the gastrointestinal symptoms of lactose intolerant subjects in the present study. Because A1 -casein at a ratio of 4:1 contains 8.3 times more A1 -casein than does milk containing only A2 -casein, it is possible that milk containing A1 -casein at a ratio of 4:1 is more toxic to intestinal cells than is milk containing only A2 -casein. Future studies should examine the effects of A1 -casein at different ratios on gastrointestinal symptoms in lactose intolerant subjects. These studies may help to clarify the true risk factors for the exacerbation of gastrointestinal symptoms by milk.

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